Loss of hepatic Flcn protects against fibrosis and inflammation by activating autophagy pathways

Loss of hepatic Flcn protects against fibrosis and inflammation by activating autophagy pathways

Abstract Non-alcoholic fatty liver disease (NAFLD) is the most frequent liver disease worldwide and can progress to non-alcoholic steatohepatitis (NASH), which is characterized by triglyceride accumulation, inflammation, and fibrosis. No pharmacological agents are currently approved to treat these c...

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Bibliographic Details
Main Authors: Mathieu Paquette, Ming Yan, Josué M. J. Ramírez-Reyes, Leeanna El-Houjeiri, Marco Biondini, Catherine R. Dufour, Hyeonju Jeong, Alain Pacis, Vincent Giguère, Jennifer L. Estall, Peter M. Siegel, Étienne Audet-Walsh, Arnim Pause
Format: Article
Language:English
Published: Nature Portfolio 2021-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-99958-7

Internet

https://doi.org/10.1038/s41598-021-99958-7

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