B7H4 Expression Is More Frequent in MSS Status Colorectal Cancer and Is Negatively Associated with Tumour Infiltrating Lymphocytes

B7H4 Expression Is More Frequent in MSS Status Colorectal Cancer and Is Negatively Associated with Tumour Infiltrating Lymphocytes

The immunotherapies based on ICIs in CRC are nowadays limited to microsatellite unstable tumours which are approximately 15% of all CRC cases. There are a few new immune checkpoints belonging to the B7 family, including B7H4. B7H4 expression is associated with so-called “cold tumours”, and its funct...

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Bibliographic Details
Main Authors: Miriam Dawidowicz, Agnieszka Kula, Sylwia Mielcarska, Paweł Kiczmer, Hanna Skiba, Małgorzata Krygier, Magdalena Chrabańska, Jerzy Piecuch, Monika Szrot, Julia Robotycka, Błażej Ochman, Bogumiła Strzałkowska, Zenon Czuba, Elżbieta Świętochowska, Dariusz Waniczek
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Cells
Subjects:
B7H4
microsatellite stable tumours
iTME
CRC
immune checkpoint
Online Access:https://www.mdpi.com/2073-4409/12/6/861

Internet

https://www.mdpi.com/2073-4409/12/6/861

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