A novel role for lipoxin A4 in driving a lymph node–eye axis that controls autoimmunity to the neuroretina

A novel role for lipoxin A4 in driving a lymph node–eye axis that controls autoimmunity to the neuroretina

The eicosanoid lipoxin A4 (LXA4) has emerging roles in lymphocyte-driven diseases. We identified reduced LXA4 levels in posterior segment uveitis patients and investigated the role of LXA4 in the pathogenesis of experimental autoimmune uveitis (EAU). Immunization for EAU with a retinal self-antigen...

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Bibliographic Details
Main Authors: Jessica Wei, Mary J Mattapallil, Reiko Horai, Yingyos Jittayasothorn, Arnav P Modi, H Nida Sen, Karsten Gronert, Rachel R Caspi
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-03-01
Series:eLife
Subjects:
effector t cells
5-lipoxygenase
uveitis
trafficking
Ccr7
draining lymph node
Online Access:https://elifesciences.org/articles/51102

Internet

https://elifesciences.org/articles/51102

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