Resveratrol Reverses Retinoic Acid Resistance of Anaplastic Thyroid Cancer Cells via Demethylating CRABP2 Gene

Resveratrol Reverses Retinoic Acid Resistance of Anaplastic Thyroid Cancer Cells via Demethylating CRABP2 Gene

Background: Cellular retinoic acid binding protein 2 (CRABP2) mediates retinoic acid/RA anti-cancer pathways. Resveratrol effectively reverses RA tolerance and upregulates CRABP2 expression of anaplastic thyroid cancer cell line THJ-11T. As DNA methylation is responsible for CRABP2 silencing, the CR...

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Bibliographic Details
Main Authors: Xin Liu, Hong Li, Mo-Li Wu, Jiao Wu, Yuan Sun, Kai-Li Zhang, Jia Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Endocrinology
Subjects:
retinoic acid
resveratrol
DNA methylation
CRABP2
DNA methyltransferase
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00734/full

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https://www.frontiersin.org/article/10.3389/fendo.2019.00734/full

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