Complex Regulation of Gamma-Hemolysin Expression Impacts Staphylococcus aureus Virulence

Complex Regulation of Gamma-Hemolysin Expression Impacts Staphylococcus aureus Virulence

ABSTRACT Staphylococcus aureus gamma-hemolysin CB (HlgCB) is a core-genome-encoded pore-forming toxin that targets the C5a receptor, similar to the phage-encoded Panton-Valentine leucocidin (PVL). Absolute quantification by mass spectrometry of HlgCB in 39 community-acquired pneumonia (CAP) isolates...

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Bibliographic Details
Main Authors: Mariane Pivard, Isabelle Caldelari, Virginie Brun, Delphine Croisier, Michel Jaquinod, Nelson Anzala, Benoît Gilquin, Chloé Teixeira, Yvonne Benito, Florence Couzon, Pascale Romby, Karen Moreau, François Vandenesch
Format: Article
Language:English
Published: American Society for Microbiology 2023-08-01
Series:Microbiology Spectrum
Subjects:
Staphylococcus aureus
gamma-hemolysin CB
toxin regulation
mRNA translation
pneumonia
rabbit model
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01073-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.01073-23

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