Regulation of human cortical interneuron development by the chromatin remodeling protein CHD2

Abstract Mutations in the chromodomain helicase DNA binding protein 2 (CHD2) gene are associated with neurodevelopmental disorders. However, mechanisms by which CHD2 regulates human brain development remain largely uncharacterized. Here, we used a human embryonic stem cell model of cortical interneu...

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Bibliographic Details
Main Authors: E. M. A. Lewis, G. Chapman, K. Kaushik, J. Determan, I. Antony, K. Meganathan, M. Narasimhan, P. Gontarz, B. Zhang, K. L. Kroll
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-19654-y