Glycyrrhetic acid synergistically enhances β₂-adrenergic receptor-Gs signaling by changing the location of Gαs in lipid rafts.

Glycyrrhetic acid synergistically enhances β₂-adrenergic receptor-Gs signaling by changing the location of Gαs in lipid rafts.

Glycyrrhetic acid (GA) exerts synergistic anti-asthmatic effects via a β₂-adrenergic receptor (β₂AR)-mediated pathway. Cholesterol is an important component of the structure and function of lipid rafts, which play critical roles in the β₂AR-Gs-adenylate cyclase (AC)-mediated signaling pathway. Owing...

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Bibliographic Details
Main Authors: Qian Shi, Yuanyuan Hou, Jie Hou, Penwei Pan, Ze Liu, Min Jiang, Jie Gao, Gang Bai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3459958?pdf=render

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http://europepmc.org/articles/PMC3459958?pdf=render

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