In vitro reconstitution of herpes simplex virus 1 fusion identifies low pH as a fusion co-trigger

In vitro reconstitution of herpes simplex virus 1 fusion identifies low pH as a fusion co-trigger

ABSTRACTMembrane fusion mediated by herpes simplex virus 1 (HSV-1) is a complex, multi-protein process that is receptor triggered and can occur both at the cell surface and in endosomes. To deconvolute this complexity, we reconstituted HSV-1 fusion with synthetic lipid vesicles in vitro. Using this...

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Bibliographic Details
Main Authors: J. Martin Ramirez, Ariana C. Calderon-Zavala, Ariane Balaram, Ekaterina E. Heldwein
Format: Article
Language:English
Published: American Society for Microbiology 2023-12-01
Series:mBio
Subjects:
HSV-1
VSV pseudotype
membrane fusion
in vitro fusion
lipids
synthetic liposomes
Online Access:https://journals.asm.org/doi/10.1128/mbio.02087-23

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