An engineered monomer binding-protein for α-synuclein efficiently inhibits the proliferation of amyloid fibrils

An engineered monomer binding-protein for α-synuclein efficiently inhibits the proliferation of amyloid fibrils

Removing or preventing the formation of [Formula: see text]-synuclein aggregates is a plausible strategy against Parkinson’s disease. To this end, we have engineered the [Formula: see text]-wrapin AS69 to bind monomeric [Formula: see text]-synuclein with high affinity. In cultured cells, AS69 reduce...

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Bibliographic Details
Main Authors: Emil Dandanell Agerschou, Patrick Flagmeier, Theodora Saridaki, Céline Galvagnion, Daniel Komnig, Laetitia Heid, Vibha Prasad, Hamed Shaykhalishahi, Dieter Willbold, Christopher M Dobson, Aaron Voigt, Bjoern Falkenburger, Wolfgang Hoyer, Alexander K Buell
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-08-01
Series:eLife
Subjects:
amyloid
inhibtion
nucleation
β-wrapin
AS69
Parkinson's disease
Online Access:https://elifesciences.org/articles/46112

Internet

https://elifesciences.org/articles/46112

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