An engineered monomer binding-protein for α-synuclein efficiently inhibits the proliferation of amyloid fibrils

Removing or preventing the formation of [Formula: see text]-synuclein aggregates is a plausible strategy against Parkinson’s disease. To this end, we have engineered the [Formula: see text]-wrapin AS69 to bind monomeric [Formula: see text]-synuclein with high affinity. In cultured cells, AS69 reduce...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Emil Dandanell Agerschou, Patrick Flagmeier, Theodora Saridaki, Céline Galvagnion, Daniel Komnig, Laetitia Heid, Vibha Prasad, Hamed Shaykhalishahi, Dieter Willbold, Christopher M Dobson, Aaron Voigt, Bjoern Falkenburger, Wolfgang Hoyer, Alexander K Buell
التنسيق:	مقال
اللغة:	English
منشور في:	eLife Sciences Publications Ltd 2019-08-01
سلاسل:	eLife
الموضوعات:	amyloid inhibtion nucleation β-wrapin AS69 Parkinson's disease
الوصول للمادة أونلاين:	https://elifesciences.org/articles/46112

الانترنت

https://elifesciences.org/articles/46112

An engineered monomer binding-protein for α-synuclein efficiently inhibits the proliferation of amyloid fibrils

الانترنت

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