Mechanisms contributing to inhibition of retinal ganglion cell death by cell permeable peptain-1 under glaucomatous stress

Mechanisms contributing to inhibition of retinal ganglion cell death by cell permeable peptain-1 under glaucomatous stress

Abstract This study assesses the neuroprotective potential of CPP-P1, a conjugate of an anti-apoptotic peptain-1 (P1) and a cell-penetrating peptide (CPP) in in vitro, in vivo, and ex vivo glaucoma models. Primary retinal ganglion cells (RGCs) were subjected to either neurotrophic factor (NF) depriv...

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Bibliographic Details
Main Authors: Gretchen A. Johnson, Bindu Kodati, Rooban B. Nahomi, Jennifer H. Pham, Vignesh R. Krishnamoorthy, Nicole R. Phillips, Raghu R. Krishnamoorthy, Ram H. Nagaraj, Dorota L. Stankowska
Format: Article
Language:English
Published: Nature Publishing Group 2024-06-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-024-02070-8

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https://doi.org/10.1038/s41420-024-02070-8

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