Transcriptomic changes triggered by ouabain in rat cerebellum granule cells: Role of α3- and α1-Na+,K+-ATPase-mediated signaling.

Transcriptomic changes triggered by ouabain in rat cerebellum granule cells: Role of α3- and α1-Na+,K+-ATPase-mediated signaling.

It was shown previously that inhibition of the ubiquitous α1 isoform of Na+,K+-ATPase by ouabain sharply affects gene expression profile via elevation of intracellular [Na+]i/[K+]i ratio. Unlike other cells, neurons are abundant in the α3 isoform of Na+,K+-ATPase, whose affinity in rodents to ouabai...

Full description

Bibliographic Details
Main Authors: Larisa V Smolyaninova, Alexandra A Shiyan, Leonid V Kapilevich, Alexander V Lopachev, Tatiana N Fedorova, Tatiana S Klementieva, Aleksey A Moskovtsev, Aslan A Kubatiev, Sergei N Orlov
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0222767

Internet

https://doi.org/10.1371/journal.pone.0222767

Similar Items