Microglial TREM2 Mitigates Inflammatory Responses and Neuronal Apoptosis in Angiotensin II-Induced Hypertension in Middle-Aged Mice

Microglial TREM2 Mitigates Inflammatory Responses and Neuronal Apoptosis in Angiotensin II-Induced Hypertension in Middle-Aged Mice

Growing evidence suggests that hypertension and aging are prominent risk factors for the development of late-onset Alzheimer’s disease (LOAD) by inducement of neuroinflammation. Recent study showed that neuroinflammation via activated microglia induces reactive astrocytes, termed A1 astrocytes, that...

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Bibliographic Details
Main Authors: Xiaotian Xu, Lin Du, Jianxiong Jiang, Ming Yang, Zhaoxia Wang, Yingge Wang, Tieyu Tang, Xuetao Fu, Jiukuan Hao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Aging Neuroscience
Subjects:
LOAD
hypertension
aging
TREM2
microglia
astrocyte
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.716917/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2021.716917/full

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