Targeting cholesterol impairs cell invasion of all breast cancer types

Targeting cholesterol impairs cell invasion of all breast cancer types

Abstract Background Breast cancer clinical outcome relies on its intrinsic molecular subtype and mortality is almost exclusively due to metastasis, whose mechanism remains unclear. We recently revealed the specific contribution of plasma membrane cholesterol to the invasion of malignant MCF10CAIa bu...

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Bibliographic Details
Main Authors: Mauriane Maja, Marie Verfaillie, Patrick Van Der Smissen, Patrick Henriet, Christophe E. Pierreux, Nor Eddine Sounni, Donatienne Tyteca
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Cancer Cell International
Subjects:
Cholesterol submicrometric domains
Breast cancer cell lines
Matrigel invasion
3D spheroid growth
3D spheroid invasion
Lipid droplets
Online Access:https://doi.org/10.1186/s12935-023-03206-z

Internet

https://doi.org/10.1186/s12935-023-03206-z

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