Adipose stem cells and their paracrine factors are therapeutic for early retinal complications of diabetes in the Ins2Akita mouse

Adipose stem cells and their paracrine factors are therapeutic for early retinal complications of diabetes in the Ins2Akita mouse

Abstract Background Early-stage diabetic retinopathy (DR) is characterized by neurovascular defects. In this study, we hypothesized that human adipose-derived stem cells (ASCs) positive for the pericyte marker CD140b, or their secreted paracrine factors, therapeutically rescue early-stage DR feature...

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Bibliographic Details
Main Authors: Sally L. Elshaer, William Evans, Mickey Pentecost, Raji Lenin, Ramesh Periasamy, Kumar Abhiram Jha, Shanta Alli, Jordy Gentry, Samuel M. Thomas, Nicolas Sohl, Rajashekhar Gangaraju
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Stem Cell Research & Therapy
Subjects:
NPDR
Adult stem cells
MSC
Vascular permeability
TSG-6
CD140b
Online Access:http://link.springer.com/article/10.1186/s13287-018-1059-y

Internet

http://link.springer.com/article/10.1186/s13287-018-1059-y

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