REST/NRSF drives homeostatic plasticity of inhibitory synapses in a target-dependent fashion

REST/NRSF drives homeostatic plasticity of inhibitory synapses in a target-dependent fashion

The repressor-element 1-silencing transcription/neuron-restrictive silencer factor (REST/NRSF) controls hundreds of neuron-specific genes. We showed that REST/NRSF downregulates glutamatergic transmission in response to hyperactivity, thus contributing to neuronal homeostasis. However, whether GABAe...

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Bibliographic Details
Main Authors: Cosimo Prestigio, Daniele Ferrante, Antonella Marte, Alessandra Romei, Gabriele Lignani, Franco Onofri, Pierluigi Valente, Fabio Benfenati, Pietro Baldelli
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-12-01
Series:eLife
Subjects:
REST/NRSF
GABAergic synapses
BDNF
synaptic homeostasis
neural hyperactivity
homeostatic plasticity
Online Access:https://elifesciences.org/articles/69058

Internet

https://elifesciences.org/articles/69058

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