A PfSPZ vaccine immunization regimen equally protective against homologous and heterologous controlled human malaria infection

A PfSPZ vaccine immunization regimen equally protective against homologous and heterologous controlled human malaria infection

Abstract Immunization with radiation-attenuated Plasmodium falciparum (Pf) sporozoites (SPZ) in PfSPZ Vaccine, has provided better vaccine efficacy (VE) against controlled human malaria infection (CHMI) with the same parasites as in the vaccine (homologous) than with genetically distant parasites (h...

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Bibliographic Details
Main Authors: Benjamin Mordmüller, Zita Sulyok, Mihály Sulyok, Zsofia Molnar, Albert Lalremruata, Carlos Lamsfus Calle, Patricia Granados Bayon, Meral Esen, Markus Gmeiner, Jana Held, Henri-Lynn Heimann, Tamirat Gebru Woldearegai, Javier Ibáñez, Judith Flügge, Rolf Fendel, Andrea Kreidenweiss, Natasha KC, Tooba Murshedkar, Sumana Chakravarty, Pouria Riyahi, Peter F. Billingsley, L. W. Preston Church, Thomas L. Richie, B. Kim Lee Sim, Stephen L. Hoffman, Peter G. Kremsner
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-022-00510-z

Internet

https://doi.org/10.1038/s41541-022-00510-z

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