Spironolactone ameliorates podocytic adhesive capacity via restoring integrin α3 expression in streptozotocin-induced diabetic rats

Podocyte responses to various injuries include detachment from the glomerular basement membrane (GBM) with impaired adhesion ability. Growing evidence suggests inappropriately enhanced aldosterone levels in glomeruli may contribute to podocytic injury and subsequently glomerulosclerosis in diabetic...

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Bibliographic Details
Main Authors: Shan Lin, Dong Li, Junya Jia, Zhenfeng Zheng, Zhonghui Jia, Wenya Shang
Format: Article
Language:English
Published: SAGE Publications 2010-09-01
Series:Journal of the Renin-Angiotensin-Aldosterone System
Online Access:https://doi.org/10.1177/1470320310369603