A transcriptional constraint mechanism limits the homeostatic response to activity deprivation in mammalian neocortex

A transcriptional constraint mechanism limits the homeostatic response to activity deprivation in mammalian neocortex

Healthy neuronal networks rely on homeostatic plasticity to maintain stable firing rates despite changing synaptic drive. These mechanisms, however, can themselves be destabilizing if activated inappropriately or excessively. For example, prolonged activity deprivation can lead to rebound hyperactiv...

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Bibliographic Details
Main Authors: Vera Valakh, Derek Wise, Xiaoyue Aelita Zhu, Mingqi Sha, Jaidyn Fok, Stephen D Van Hooser, Robin Schectman, Isabel Cepeda, Ryan Kirk, Sean M O'Toole, Sacha B Nelson
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-02-01
Series:eLife
Subjects:
homeostatic plasticity
synapse
neocortex
mouse
neuron
Online Access:https://elifesciences.org/articles/74899

Internet

https://elifesciences.org/articles/74899

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