Induced-Decay of Glycine Decarboxylase Transcripts as an Anticancer Therapeutic Strategy for Non-Small-Cell Lung Carcinoma

Induced-Decay of Glycine Decarboxylase Transcripts as an Anticancer Therapeutic Strategy for Non-Small-Cell Lung Carcinoma

Self-renewing tumor-initiating cells (TICs) are thought to be responsible for tumor recurrence and chemo-resistance. Glycine decarboxylase, encoded by the GLDC gene, is reported to be overexpressed in TIC-enriched primary non-small-cell lung carcinoma (NSCLC). GLDC is a component of the mitochondria...

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Bibliographic Details
Main Authors: Jing Lin, Jia Hui Jane Lee, Kathirvel Paramasivam, Elina Pathak, Zhenxun Wang, Zacharias Aloysius Dwi Pramono, Bing Lim, Keng Boon Wee, Uttam Surana
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
antisense oligonucleotides
glycine decarboxylase
tumor-initiating cells
lung cancer
RNA splicing
exon skipping
nonsense-mediated decay
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253117302627

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http://www.sciencedirect.com/science/article/pii/S2162253117302627

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