A renal clearable fluorogenic probe for in vivo β-galactosidase activity detection during aging and senolysis

A renal clearable fluorogenic probe for in vivo β-galactosidase activity detection during aging and senolysis

Abstract Accumulation of senescent cells with age leads to tissue dysfunction and related diseases. Their detection in vivo still constitutes a challenge in aging research. We describe the generation of a fluorogenic probe (sulfonic-Cy7Gal) based on a galactose derivative, to serve as substrate for...

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Bibliographic Details
Main Authors: Sara Rojas-Vázquez, Beatriz Lozano-Torres, Alba García-Fernández, Irene Galiana, Ana Perez-Villalba, Pablo Martí-Rodrigo, M. José Palop, Marcia Domínguez, Mar Orzáez, Félix Sancenón, Juan F. Blandez, Isabel Fariñas, Ramón Martínez-Máñez
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-44903-1

Internet

https://doi.org/10.1038/s41467-024-44903-1

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