Multiple circulating alkaloids and saponins from intravenous Kang-Ai injection inhibit human cytochrome P450 and UDP-glucuronosyltransferase isozymes: potential drug–drug interactions

Multiple circulating alkaloids and saponins from intravenous Kang-Ai injection inhibit human cytochrome P450 and UDP-glucuronosyltransferase isozymes: potential drug–drug interactions

Abstract Background Kang-Ai injection is widely used as an adjuvant therapy drug for many cancers, leukopenia, and chronic hepatitis B. Circulating alkaloids and saponins are believed to be responsible for therapeutic effects. However, their pharmacokinetics (PK) and excretion in vivo and the risk o...

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Bibliographic Details
Main Authors: Zifei Qin, Mengmeng Jia, Jing Yang, Han Xing, Zhao Yin, Zhihong Yao, Xiaojian Zhang, Xinsheng Yao
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Chinese Medicine
Subjects:
Kang-Ai injection
Pharmacokinetics
Excretion
Plasma protein binding rate
Cytochrome P450
UDP-glucuronosyltransferase
Online Access:http://link.springer.com/article/10.1186/s13020-020-00349-3

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http://link.springer.com/article/10.1186/s13020-020-00349-3

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