The Role of Glycogen Synthase Kinase-3 in the Regulation of Ribosome Biogenesis in Rat Soleus Muscle under Disuse Conditions

The Role of Glycogen Synthase Kinase-3 in the Regulation of Ribosome Biogenesis in Rat Soleus Muscle under Disuse Conditions

It is well-established that prolonged exposure to real or simulated microgravity/disuse conditions results in a significant reduction in the rate of muscle protein synthesis (PS) and loss of muscle mass. Muscle protein synthesis is largely dependent upon translational capacity (ribosome content), th...

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Bibliographic Details
Main Authors: Sergey V. Rozhkov, Kristina A. Sharlo, Boris S. Shenkman, Timur M. Mirzoev
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:International Journal of Molecular Sciences
Subjects:
soleus muscle
hindlimb unloading
simulated microgravity
GSK-3
ribosome biogenesis
muscle protein synthesis
Online Access:https://www.mdpi.com/1422-0067/23/5/2751

Internet

https://www.mdpi.com/1422-0067/23/5/2751

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