Subtilisin of <i>Leishmania amazonensis</i> as Potential Druggable Target: Subcellular Localization, In Vitro Leishmanicidal Activity and Molecular Docking of PF-429242, a Subtilisin Inhibitor

Subtilisin of <i>Leishmania amazonensis</i> as Potential Druggable Target: Subcellular Localization, In Vitro Leishmanicidal Activity and Molecular Docking of PF-429242, a Subtilisin Inhibitor

Subtilisin proteases, found in all organisms, are enzymes important in the post-translational steps of protein processing. In <i>Leishmania major</i> and <i>L. donovani</i>, this enzyme has been described as essential to their survival; however, few compounds that target subt...

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Bibliographic Details
Main Authors: Pollyanna Stephanie Gomes, Monique Pacheco Duarte Carneiro, Patrícia de Almeida Machado, Valter Viana de Andrade-Neto, Alessandra Marcia da Fonseca-Martins, Amy Goundry, João Vitor Marques Pereira da Silva, Daniel Claudio Oliveira Gomes, Ana Paula Cabral de Araujo Lima, Vítor Ennes-Vidal, Ana Carolina Rennó Sodero, Salvatore Giovanni De-Simone, Herbert L. de Matos Guedes
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Current Issues in Molecular Biology
Subjects:
<i>Leishmania</i>
serine protease
subtilisin
PF-429242
cellular localization
Online Access:https://www.mdpi.com/1467-3045/44/5/141

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https://www.mdpi.com/1467-3045/44/5/141

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