A novel rhein-huprine hybrid ameliorates disease-modifying properties in preclinical mice model of Alzheimer’s disease exacerbated with high fat diet

A novel rhein-huprine hybrid ameliorates disease-modifying properties in preclinical mice model of Alzheimer’s disease exacerbated with high fat diet

Abstract Background Alzheimer’s disease (AD) is characterized by a polyetiological origin. Despite the global burden of AD and the advances made in AD drug research and development, the cure of the disease remains elusive, since any developed drug has demonstrated effectiveness to cure AD. Strikingl...

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Bibliographic Details
Main Authors: Triana Espinosa-Jiménez, Amanda Cano, Elena Sánchez-López, Jordi Olloquequi, Jaume Folch, Mònica Bulló, Ester Verdaguer, Carme Auladell, Caterina Pont, Diego Muñoz-Torrero, Antoni Parcerisas, Antoni Camins, Miren Ettcheto
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Cell & Bioscience
Subjects:
Rhein-huprine hybrid
Dendritic spines
Cognitive decline
Alzheimer’s disease
High-fat diet
BDNF
Online Access:https://doi.org/10.1186/s13578-023-01000-y

Internet

https://doi.org/10.1186/s13578-023-01000-y

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