A mechanism-based pharmacokinetic model of fenofibrate for explaining increased drug absorption after food consumption

A mechanism-based pharmacokinetic model of fenofibrate for explaining increased drug absorption after food consumption

Abstract Background Oral administration of drugs is convenient and shows good compliance but it can be affected by many factors in the gastrointestinal (GI) system. Consumption of food is one of the major factors affecting the GI system and consequently the absorption of drugs. The aim of this study...

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Bibliographic Details
Main Authors: Hyun-moon Back, Byungjeong Song, Sudeep Pradhan, Jung-woo Chae, Nayoung Han, Wonku Kang, Min Jung Chang, Jiao Zheng, Kwang-il Kwon, Mats O. Karlsson, Hwi-yeol Yun
Format: Article
Language:English
Published: BMC 2018-01-01
Series:BMC Pharmacology and Toxicology
Subjects:
Food effect
Gastrointestinal system
Fenofibrate
NONMEM
Drug absorption
Online Access:http://link.springer.com/article/10.1186/s40360-018-0194-5

Internet

http://link.springer.com/article/10.1186/s40360-018-0194-5

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