Structure-based inhibitor design for reshaping bacterial morphology
Peptidoglycan hydrolase 3 (Pgp3) inhibitors are designed that can change the helical morphology of Campylobacter jejuni to rod-shaped and decrease its virulence.
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-04-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-03355-3 |
| _version_ | 1811289391728951296 |
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| author | Yuri Choi Ji Su Park Jinshil Kim Kyungjin Min Kiran Mahasenan Choon Kim Hye-Jin Yoon Sewon Lim Dae Hee Cheon Yan Lee Sangryeol Ryu Shahriar Mobashery B. Moon Kim Hyung Ho Lee |
| author_facet | Yuri Choi Ji Su Park Jinshil Kim Kyungjin Min Kiran Mahasenan Choon Kim Hye-Jin Yoon Sewon Lim Dae Hee Cheon Yan Lee Sangryeol Ryu Shahriar Mobashery B. Moon Kim Hyung Ho Lee |
| author_sort | Yuri Choi |
| collection | DOAJ |
| description | Peptidoglycan hydrolase 3 (Pgp3) inhibitors are designed that can change the helical morphology of Campylobacter jejuni to rod-shaped and decrease its virulence. |
| first_indexed | 2024-04-13T03:55:11Z |
| format | Article |
| id | doaj.art-14a44cf5a1054c018de8b0c7a7924892 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-13T03:55:11Z |
| publishDate | 2022-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-14a44cf5a1054c018de8b0c7a79248922022-12-22T03:03:40ZengNature PortfolioCommunications Biology2399-36422022-04-015111010.1038/s42003-022-03355-3Structure-based inhibitor design for reshaping bacterial morphologyYuri Choi0Ji Su Park1Jinshil Kim2Kyungjin Min3Kiran Mahasenan4Choon Kim5Hye-Jin Yoon6Sewon Lim7Dae Hee Cheon8Yan Lee9Sangryeol Ryu10Shahriar Mobashery11B. Moon Kim12Hyung Ho Lee13Department of Chemistry, College of Natural Sciences, Seoul National UniversityDepartment of Chemistry, College of Natural Sciences, Seoul National UniversityDepartment of Food and Animal Biotechnology, Department of Agricultural Biotechnology, Research Institute for Agriculture and Life Sciences, Seoul National UniversityDepartment of Chemistry, College of Natural Sciences, Seoul National UniversityDepartment of Chemistry and Biochemistry, University of Notre DameDepartment of Chemistry and Biochemistry, University of Notre DameDepartment of Chemistry, College of Natural Sciences, Seoul National UniversityDepartment of Chemistry, College of Natural Sciences, Seoul National UniversityDepartment of Chemistry, College of Natural Sciences, Seoul National UniversityDepartment of Chemistry, College of Natural Sciences, Seoul National UniversityDepartment of Food and Animal Biotechnology, Department of Agricultural Biotechnology, Research Institute for Agriculture and Life Sciences, Seoul National UniversityDepartment of Chemistry and Biochemistry, University of Notre DameDepartment of Chemistry, College of Natural Sciences, Seoul National UniversityDepartment of Chemistry, College of Natural Sciences, Seoul National UniversityPeptidoglycan hydrolase 3 (Pgp3) inhibitors are designed that can change the helical morphology of Campylobacter jejuni to rod-shaped and decrease its virulence.https://doi.org/10.1038/s42003-022-03355-3 |
| spellingShingle | Yuri Choi Ji Su Park Jinshil Kim Kyungjin Min Kiran Mahasenan Choon Kim Hye-Jin Yoon Sewon Lim Dae Hee Cheon Yan Lee Sangryeol Ryu Shahriar Mobashery B. Moon Kim Hyung Ho Lee Structure-based inhibitor design for reshaping bacterial morphology Communications Biology |
| title | Structure-based inhibitor design for reshaping bacterial morphology |
| title_full | Structure-based inhibitor design for reshaping bacterial morphology |
| title_fullStr | Structure-based inhibitor design for reshaping bacterial morphology |
| title_full_unstemmed | Structure-based inhibitor design for reshaping bacterial morphology |
| title_short | Structure-based inhibitor design for reshaping bacterial morphology |
| title_sort | structure based inhibitor design for reshaping bacterial morphology |
| url | https://doi.org/10.1038/s42003-022-03355-3 |
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