DUBing Primary Tumors of the Central Nervous System: Regulatory Roles of Deubiquitinases

DUBing Primary Tumors of the Central Nervous System: Regulatory Roles of Deubiquitinases

The ubiquitin proteasome system (UPS) utilizes an orchestrated enzymatic cascade of E1, E2, and E3 ligases to add single or multiple ubiquitin-like molecules as post-translational modification (PTM) to proteins. Ubiquitination can alter protein functions and/or mark ubiquitinated proteins for protea...

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Bibliographic Details
Main Authors: Thomas Klonisch, Susan E. Logue, Sabine Hombach-Klonisch, Jerry Vriend
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Biomolecules
Subjects:
brain tumor
glioma
neuronal system tumor
deubiquitinase (DUB)
endoplasmic reticulum associated degradation (ERAD)
immune response
Online Access:https://www.mdpi.com/2218-273X/13/10/1503

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https://www.mdpi.com/2218-273X/13/10/1503

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