Unveiling the dark side of glucose-regulated protein 78 (GRP78) in cancers and other human pathology: a systematic review

Unveiling the dark side of glucose-regulated protein 78 (GRP78) in cancers and other human pathology: a systematic review

Abstract Glucose-Regulated Protein 78 (GRP78) is a chaperone protein that is predominantly expressed in the lumen of the endoplasmic reticulum. GRP78 plays a crucial role in protein folding by assisting in the assembly of misfolded proteins. Under cellular stress conditions, GRP78 can translocate to...

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Bibliographic Details
Main Authors: Amos Olalekan Akinyemi, Kendall Elizabeth Simpson, Sunday Faith Oyelere, Maria Nur, Chrispus Mutuku Ngule, Bolaji Charles Dayo Owoyemi, Vivian Adiila Ayarick, Felix Femi Oyelami, Oluwafunminiyi Obaleye, Dave-Preston Esoe, Xiaoqi Liu, Zhiguo Li
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Molecular Medicine
Subjects:
Cancer
GRP78
BiP
Disease
ER stress
ERAD
Online Access:https://doi.org/10.1186/s10020-023-00706-6

Internet

https://doi.org/10.1186/s10020-023-00706-6

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