Unveiling the dark side of glucose-regulated protein 78 (GRP78) in cancers and other human pathology: a systematic review
Abstract Glucose-Regulated Protein 78 (GRP78) is a chaperone protein that is predominantly expressed in the lumen of the endoplasmic reticulum. GRP78 plays a crucial role in protein folding by assisting in the assembly of misfolded proteins. Under cellular stress conditions, GRP78 can translocate to...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | Molecular Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s10020-023-00706-6 |
| _version_ | 1797558917052497920 |
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| author | Amos Olalekan Akinyemi Kendall Elizabeth Simpson Sunday Faith Oyelere Maria Nur Chrispus Mutuku Ngule Bolaji Charles Dayo Owoyemi Vivian Adiila Ayarick Felix Femi Oyelami Oluwafunminiyi Obaleye Dave-Preston Esoe Xiaoqi Liu Zhiguo Li |
| author_facet | Amos Olalekan Akinyemi Kendall Elizabeth Simpson Sunday Faith Oyelere Maria Nur Chrispus Mutuku Ngule Bolaji Charles Dayo Owoyemi Vivian Adiila Ayarick Felix Femi Oyelami Oluwafunminiyi Obaleye Dave-Preston Esoe Xiaoqi Liu Zhiguo Li |
| author_sort | Amos Olalekan Akinyemi |
| collection | DOAJ |
| description | Abstract Glucose-Regulated Protein 78 (GRP78) is a chaperone protein that is predominantly expressed in the lumen of the endoplasmic reticulum. GRP78 plays a crucial role in protein folding by assisting in the assembly of misfolded proteins. Under cellular stress conditions, GRP78 can translocate to the cell surface (csGRP78) were it interacts with different ligands to initiate various intracellular pathways. The expression of csGRP78 has been associated with tumor initiation and progression of multiple cancer types. This review provides a comprehensive analysis of the existing evidence on the roles of GRP78 in various types of cancer and other human pathology. Additionally, the review discusses the current understanding of the mechanisms underlying GRP78's involvement in tumorigenesis and cancer advancement. Furthermore, we highlight recent innovative approaches employed in downregulating GRP78 expression in cancers as a potential therapeutic target. |
| first_indexed | 2024-03-10T17:38:17Z |
| format | Article |
| id | doaj.art-14a8421fbe00410b953e5de3f8eff2ab |
| institution | Directory Open Access Journal |
| issn | 1528-3658 |
| language | English |
| last_indexed | 2024-03-10T17:38:17Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Medicine |
| spelling | doaj.art-14a8421fbe00410b953e5de3f8eff2ab2023-11-20T09:46:23ZengBMCMolecular Medicine1528-36582023-08-0129113310.1186/s10020-023-00706-6Unveiling the dark side of glucose-regulated protein 78 (GRP78) in cancers and other human pathology: a systematic reviewAmos Olalekan Akinyemi0Kendall Elizabeth Simpson1Sunday Faith Oyelere2Maria Nur3Chrispus Mutuku Ngule4Bolaji Charles Dayo Owoyemi5Vivian Adiila Ayarick6Felix Femi Oyelami7Oluwafunminiyi Obaleye8Dave-Preston Esoe9Xiaoqi Liu10Zhiguo Li11Department of Toxicology and Cancer Biology, University of KentuckyDepartment of Toxicology and Cancer Biology, University of KentuckyDepartment of Biology, Heinrich-Heine-UniversitätDepartment of Toxicology and Cancer Biology, University of KentuckyDepartment of Toxicology and Cancer Biology, University of KentuckyDepartment of Pharmaceutical Science, University of São Paulo (USP)Department of Toxicology and Cancer Biology, University of KentuckyDepartment of Toxicology and Cancer Biology, University of KentuckyDepartment of Toxicology and Cancer Biology, University of KentuckyDepartment of Toxicology and Cancer Biology, University of KentuckyDepartment of Toxicology and Cancer Biology, University of KentuckyDepartment of Toxicology and Cancer Biology, University of KentuckyAbstract Glucose-Regulated Protein 78 (GRP78) is a chaperone protein that is predominantly expressed in the lumen of the endoplasmic reticulum. GRP78 plays a crucial role in protein folding by assisting in the assembly of misfolded proteins. Under cellular stress conditions, GRP78 can translocate to the cell surface (csGRP78) were it interacts with different ligands to initiate various intracellular pathways. The expression of csGRP78 has been associated with tumor initiation and progression of multiple cancer types. This review provides a comprehensive analysis of the existing evidence on the roles of GRP78 in various types of cancer and other human pathology. Additionally, the review discusses the current understanding of the mechanisms underlying GRP78's involvement in tumorigenesis and cancer advancement. Furthermore, we highlight recent innovative approaches employed in downregulating GRP78 expression in cancers as a potential therapeutic target.https://doi.org/10.1186/s10020-023-00706-6CancerGRP78BiPDiseaseER stressERAD |
| spellingShingle | Amos Olalekan Akinyemi Kendall Elizabeth Simpson Sunday Faith Oyelere Maria Nur Chrispus Mutuku Ngule Bolaji Charles Dayo Owoyemi Vivian Adiila Ayarick Felix Femi Oyelami Oluwafunminiyi Obaleye Dave-Preston Esoe Xiaoqi Liu Zhiguo Li Unveiling the dark side of glucose-regulated protein 78 (GRP78) in cancers and other human pathology: a systematic review Molecular Medicine Cancer GRP78 BiP Disease ER stress ERAD |
| title | Unveiling the dark side of glucose-regulated protein 78 (GRP78) in cancers and other human pathology: a systematic review |
| title_full | Unveiling the dark side of glucose-regulated protein 78 (GRP78) in cancers and other human pathology: a systematic review |
| title_fullStr | Unveiling the dark side of glucose-regulated protein 78 (GRP78) in cancers and other human pathology: a systematic review |
| title_full_unstemmed | Unveiling the dark side of glucose-regulated protein 78 (GRP78) in cancers and other human pathology: a systematic review |
| title_short | Unveiling the dark side of glucose-regulated protein 78 (GRP78) in cancers and other human pathology: a systematic review |
| title_sort | unveiling the dark side of glucose regulated protein 78 grp78 in cancers and other human pathology a systematic review |
| topic | Cancer GRP78 BiP Disease ER stress ERAD |
| url | https://doi.org/10.1186/s10020-023-00706-6 |
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