DNA Damage Repair Gene Set as a Potential Biomarker for Stratifying Patients with High Tumor Mutational Burden

DNA Damage Repair Gene Set as a Potential Biomarker for Stratifying Patients with High Tumor Mutational Burden

Tumor mutational burden (TMB) is a promising predictive biomarker for cancer immunotherapy. Patients with a high TMB have better responses to immune checkpoint inhibitors. Currently, the gold standard for determining TMB is whole-exome sequencing (WES). However, high cost, long turnaround time, infr...

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Bibliographic Details
Main Authors: To-Yuan Chiu, Ryan Weihsiang Lin, Chien-Jung Huang, Da-Wei Yeh, Yu-Chao Wang
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Biology
Subjects:
tumor mutational burden
DNA damage repair genes
immunotherapy
biomarker
biomedical informatics
Online Access:https://www.mdpi.com/2079-7737/10/6/528

Internet

https://www.mdpi.com/2079-7737/10/6/528

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