Low‐burden TP53 mutations represent frequent genetic events in CLL with an increased risk for treatment initiation
Abstract TP53 aberrations predict chemoresistance and represent a contraindication for the use of standard chemoimmunotherapy in chronic lymphocytic leukaemia (CLL). Recent next‐generation sequencing (NGS)‐based studies have identified frequent low‐burden TP53 mutations with variant allele frequenci...
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Wiley
2024-01-01
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Series: | The Journal of Pathology: Clinical Research |
Subjects: | |
Online Access: | https://doi.org/10.1002/cjp2.351 |