Comparison of LC-MS/MS and EMIT methods for the precise determination of blood sirolimus in children with vascular anomalies

Comparison of LC-MS/MS and EMIT methods for the precise determination of blood sirolimus in children with vascular anomalies

Sirolimus (SRL) is a mammalian target of rapamycin (mTOR) inhibitor. The whole blood concentration of SRL is routinely monitored to tailor dosage and prevent toxicity. Currently, the enzyme multiplied immunoassay technique (EMIT) is often applied to perform therapeutic drug monitoring (TDM) of SRL,...

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Bibliographic Details
Main Authors: Yue-Tao Zhao, Hao-Ran Dai, Yue Li, Yuan-Yuan Zhang, Hong-Li Guo, Xuan-Sheng Ding, Ya-Hui Hu, Feng Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
sirolimus
EMIT
LC-MS/MS
TDM
consistency
children
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.925018/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.925018/full

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