Structural identification of vasodilator binding sites on the SUR2 subunit

Structural identification of vasodilator binding sites on the SUR2 subunit

SUR2-containing KATP channels are drug targets for certain vasodilators. Here, the authors determine high-resolution cryo-EM structures of SUR2 in complex with two vasodilators, P1075 and levcromakalim, uncovering the mechanisms of these drugs.

Bibliographic Details
Main Authors: Dian Ding, Jing-Xiang Wu, Xinli Duan, Songling Ma, Lipeng Lai, Lei Chen
Format: Article
Language:English
Published: Nature Portfolio 2022-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-30428-y

Internet

https://doi.org/10.1038/s41467-022-30428-y

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