Regression of Atherosclerosis in ApoE−/− Mice Via Modulation of Monocyte Recruitment and Phenotype, Induced by Weekly Dosing of a Novel “Cytotopic” Anti‐Thrombin Without Prolonged Anticoagulation

Regression of Atherosclerosis in ApoE−/− Mice Via Modulation of Monocyte Recruitment and Phenotype, Induced by Weekly Dosing of a Novel “Cytotopic” Anti‐Thrombin Without Prolonged Anticoagulation

Background Anticoagulants induce atherosclerosis regression in animal models but exploiting this clinically is limited by bleeding events. Here we test a novel thrombin inhibitor, PTL060, comprising hirulog covalently linked to a synthetic myristoyl electrostatic switch to tether to cell membranes....

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Bibliographic Details
Main Authors: Daxin Chen, Ke Li, Sam Festenstein, Julieta Karegli, Hannah Wilkinson, Hugh Leonard, Lin‐Lin Wei, Ning Ma, Min Xia, Henry Tam, Jian‐an Wang, Qingbo Xu, John H. McVey, Richard A. G. Smith, Anthony Dorling
Format: Article
Language:English
Published: Wiley 2020-07-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
atherosclerosis
regression
thrombin
thrombin inhibitor
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.119.014811

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.119.014811

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