Suppressor of Cytokine Signaling 2 Regulates Retinal Pigment Epithelium Metabolism by Enhancing Autophagy

Suppressor of Cytokine Signaling 2 Regulates Retinal Pigment Epithelium Metabolism by Enhancing Autophagy

Retinal pigment epithelium (RPE) serves critical functions in maintaining retinal homeostasis. An important function of RPE is to degrade the photoreceptor outer segment fragments daily to maintain photoreceptor function and longevity throughout life. An impairment of RPE functions such as metabolic...

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Bibliographic Details
Main Authors: Xi-Yuan Liu, Rui Lu, Jing Chen, Jie Wang, Hong-Mei Qian, Gang Chen, Rong-Han Wu, Zai-Long Chi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Neuroscience
Subjects:
suppressor of cytokine signaling 2
retinal pigment epithelium
autophagy
ubiquitin
glycogen synthase kinase (GSK)-3β
mammalian target of rapamycin (mTOR)
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.738022/full

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https://www.frontiersin.org/articles/10.3389/fnins.2021.738022/full

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