JNK Activation Correlates with Cognitive Impairment and Alteration of the Post-Synaptic Element in the 5xFAD AD Mouse Model

JNK Activation Correlates with Cognitive Impairment and Alteration of the Post-Synaptic Element in the 5xFAD AD Mouse Model

The c-Jun N-terminal kinases (JNKs) are a family of proteins that, once activated by stress stimuli, can alter neuronal functions and survival. The JNK cascade plays a crucial role in the post-synaptic neuronal compartment by altering its structural organization and leading, at worst, to an overall...

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Bibliographic Details
Main Authors: Erica Cecilia Priori, Clara Alice Musi, Arianna Giani, Luca Colnaghi, Ivana Milic, Andrew Devitt, Tiziana Borsello, Mariaelena Repici
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Cells
Subjects:
c-Jun N-terminal kinase
synaptic dysfunction
cognitive decline
cell death
Online Access:https://www.mdpi.com/2073-4409/12/6/904

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https://www.mdpi.com/2073-4409/12/6/904

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