Spatiotemporal Analysis of B Cell- and Antibody Secreting Cell-Subsets in Human Melanoma Reveals Metastasis-, Tumor Stage-, and Age-Associated Dynamics

Spatiotemporal Analysis of B Cell- and Antibody Secreting Cell-Subsets in Human Melanoma Reveals Metastasis-, Tumor Stage-, and Age-Associated Dynamics

Background: The role of tumor-associated B cells in human cancer is only starting to emerge. B cells typically undergo a series of developmental changes in phenotype and function, however, data on the composition of the B cell population in human melanoma are largely absent including changes during...

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Bibliographic Details
Main Authors: Minyi Chen, Franziska Werner, Christine Wagner, Martin Simon, Erika Richtig, Kirsten D. Mertz, Johannes Griss, Stephan N. Wagner
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
tumor-associated B cells
memory B cells
plasma cells
human melanoma
tumor microenvironment
multiplex immunohistochemistry
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.677944/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.677944/full

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