A graph-based approach for proteoform identification and quantification using top-down homogeneous multiplexed tandem mass spectra

A graph-based approach for proteoform identification and quantification using top-down homogeneous multiplexed tandem mass spectra

Abstract Background Top-down homogeneous multiplexed tandem mass (HomMTM) spectra are generated from modified proteoforms of the same protein with different post-translational modification patterns. They are frequently observed in the analysis of ultramodified proteins, some proteoforms of which hav...

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Bibliographic Details
Main Authors: Kaiyuan Zhu, Xiaowen Liu
Format: Article
Language:English
Published: BMC 2018-08-01
Series:BMC Bioinformatics
Subjects:
Mass spectrometry
Top-down
Multiplexed mass spectra
Graph algorithms
Online Access:http://link.springer.com/article/10.1186/s12859-018-2273-4

Internet

http://link.springer.com/article/10.1186/s12859-018-2273-4

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