Acetylcholine Reduces I<sub>Kr</sub> and Prolongs Action Potentials in Human Ventricular Cardiomyocytes

Vagal nerve stimulation (VNS) has a meaningful basis as a potentially effective treatment for heart failure with reduced ejection fraction. There is an ongoing VNS randomized study, and four studies are completed. However, relatively little is known about the effect of acetylcholine (ACh) on repolar...

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Bibliographic Details
Main Authors: István Koncz, Arie O. Verkerk, Michele Nicastro, Ronald Wilders, Tamás Árpádffy-Lovas, Tibor Magyar, Noémi Tóth, Norbert Nagy, Micah Madrid, Zexu Lin, Igor R. Efimov
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Biomedicines
Subjects:
Online Access:https://www.mdpi.com/2227-9059/10/2/244