Inhibition of monoamine oxidases by benzimidazole chalcone derivatives

Inhibition of monoamine oxidases by benzimidazole chalcone derivatives

Abstract Ten benzimidazole chalcone derivatives were synthesized, and their monoamine oxidase (MAO) inhibitory activity was evaluated. Most compounds showed higher inhibitory activity against MAO-B than MAO-A. Compound BCH2 exhibited an IC50 value of 0.80 μM, thereby showing the most potent inhibiti...

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Bibliographic Details
Main Authors: Athulya Krishna, Jiseong Lee, Sunil Kumar, Sachithra Thazhathuveedu Sudevan, Prerna Uniyal, Leena K. Pappachen, Hoon Kim, Bijo Mathew
Format: Article
Language:English
Published: SpringerOpen 2023-06-01
Series:Applied Biological Chemistry
Subjects:
Benzimidazole
Chalcones
MAO-A
MAO-B
Kinetics
Molecular docking
Online Access:https://doi.org/10.1186/s13765-023-00795-1

Internet

https://doi.org/10.1186/s13765-023-00795-1

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