One substrate many enzymes virtual screening uncovers missing genes of carnitine biosynthesis in human and mouse

One substrate many enzymes virtual screening uncovers missing genes of carnitine biosynthesis in human and mouse

Abstract The increasing availability of experimental and computational protein structures entices their use for function prediction. Here we develop an automated procedure to identify enzymes involved in metabolic reactions by assessing substrate conformations docked to a library of protein structur...

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Bibliographic Details
Main Authors: Marco Malatesta, Emanuele Fornasier, Martino Luigi Di Salvo, Angela Tramonti, Erika Zangelmi, Alessio Peracchi, Andrea Secchi, Eugenia Polverini, Gabriele Giachin, Roberto Battistutta, Roberto Contestabile, Riccardo Percudani
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-47466-3

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https://doi.org/10.1038/s41467-024-47466-3

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