In vitro co-culture systems of hepatic and intestinal cells for cellular pharmacokinetic and pharmacodynamic studies of capecitabine against colorectal cancer

In vitro co-culture systems of hepatic and intestinal cells for cellular pharmacokinetic and pharmacodynamic studies of capecitabine against colorectal cancer

Abstract Background As a prodrug of 5-fluorouracil (5-FU), orally administrated capecitabine (CAP) undergoes preliminary conversion into active metabolites in the liver and then releases 5-FU in the gut to exert the anti-tumor activity. Since metabolic changes of CAP play a key role in its activatio...

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Bibliographic Details
Main Authors: Chun Ge, Xintong Huang, Sujie Zhang, Man Yuan, Zhaoyi Tan, Chen Xu, Qiong Jie, Jingjing Zhang, Jianjun Zou, Yubing Zhu, Dong Feng, Yue Zhang, Jiye Aa
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Cancer Cell International
Subjects:
Cellular pharmacokinetics
Cellular pharmacodynamics
Capecitabine
Co-culture
Prodrug
Online Access:https://doi.org/10.1186/s12935-023-02853-6

Internet

https://doi.org/10.1186/s12935-023-02853-6

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