Long-term social isolation stress exacerbates sex-specific neurodegeneration markers in a natural model of Alzheimer’s disease
Social interactions have a significant impact on health in humans and animal models. Social isolation initiates a cascade of stress-related physiological disorders and stands as a significant risk factor for a wide spectrum of morbidity and mortality. Indeed, social isolation stress (SIS) is indicat...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1250342/full |
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| author | Carolina A. Oliva Matías Lira Matías Lira Claudia Jara Alejandra Catenaccio Alejandra Catenaccio Trinidad A. Mariqueo Carolina B. Lindsay Francisco Bozinovic Grisel Cavieres Grisel Cavieres Nibaldo C. Inestrosa Nibaldo C. Inestrosa Cheril Tapia-Rojas Cheril Tapia-Rojas Daniela S. Rivera |
| author_facet | Carolina A. Oliva Matías Lira Matías Lira Claudia Jara Alejandra Catenaccio Alejandra Catenaccio Trinidad A. Mariqueo Carolina B. Lindsay Francisco Bozinovic Grisel Cavieres Grisel Cavieres Nibaldo C. Inestrosa Nibaldo C. Inestrosa Cheril Tapia-Rojas Cheril Tapia-Rojas Daniela S. Rivera |
| author_sort | Carolina A. Oliva |
| collection | DOAJ |
| description | Social interactions have a significant impact on health in humans and animal models. Social isolation initiates a cascade of stress-related physiological disorders and stands as a significant risk factor for a wide spectrum of morbidity and mortality. Indeed, social isolation stress (SIS) is indicative of cognitive decline and risk to neurodegenerative conditions, including Alzheimer’s disease (AD). This study aimed to evaluate the impact of chronic, long-term SIS on the propensity to develop hallmarks of AD in young degus (Octodon degus), a long-lived animal model that mimics sporadic AD naturally. We examined inflammatory factors, bioenergetic status, reactive oxygen species (ROS), oxidative stress, antioxidants, abnormal proteins, tau protein, and amyloid-β (Aβ) levels in the hippocampus of female and male degus that were socially isolated from post-natal and post-weaning until adulthood. Additionally, we explored the effect of re-socialization following chronic isolation on these protein profiles. Our results showed that SIS promotes a pro-inflammatory scenario more severe in males, a response that was partially mitigated by a period of re-socialization. In addition, ATP levels, ROS, and markers of oxidative stress are severely affected in female degus, where a period of re-socialization fails to restore them as it does in males. In females, these effects might be linked to antioxidant enzymes like catalase, which experience a decline across all SIS treatments without recovery during re-socialization. Although in males, a previous enzyme in antioxidant pathway diminishes in all treatments, catalase rebounds during re-socialization. Notably, males have less mature neurons after chronic isolation, whereas phosphorylated tau and all detectable forms of Aβ increased in both sexes, persisting even post re-socialization. Collectively, these findings suggest that long-term SIS may render males more susceptible to inflammatory states, while females are predisposed to oxidative states. In both scenarios, the accumulation of tau and Aβ proteins increase the individual susceptibility to early-onset neurodegenerative conditions such as AD. |
| first_indexed | 2024-03-11T22:34:32Z |
| format | Article |
| id | doaj.art-14d0878ab9b747d19ede0b7e1c46b3ee |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-03-11T22:34:32Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-14d0878ab9b747d19ede0b7e1c46b3ee2023-09-22T16:43:18ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652023-09-011510.3389/fnagi.2023.12503421250342Long-term social isolation stress exacerbates sex-specific neurodegeneration markers in a natural model of Alzheimer’s diseaseCarolina A. Oliva0Matías Lira1Matías Lira2Claudia Jara3Alejandra Catenaccio4Alejandra Catenaccio5Trinidad A. Mariqueo6Carolina B. Lindsay7Francisco Bozinovic8Grisel Cavieres9Grisel Cavieres10Nibaldo C. Inestrosa11Nibaldo C. Inestrosa12Cheril Tapia-Rojas13Cheril Tapia-Rojas14Daniela S. Rivera15Centro para la Transversalización de Género en I+D+i+e, Vicerrectoría de Investigación y Doctorados, Universidad Autónoma de Chile, Santiago, ChileLaboratory of Neurobiology of Aging, Centro de Biología Celular y Biomedicina (CEBICEM), Facultad de Medicina y Ciencia, Universidad San Sebastián, Santiago, ChileCentro Científico y Tecnológico de Excelencia Ciencia & Vida, Santiago, ChileLaboratory of Neurobiology of Aging, Centro de Biología Celular y Biomedicina (CEBICEM), Facultad de Medicina y Ciencia, Universidad San Sebastián, Santiago, ChileLaboratory of Neurobiology of Aging, Centro de Biología Celular y Biomedicina (CEBICEM), Facultad de Medicina y Ciencia, Universidad San Sebastián, Santiago, ChileCentro Científico y Tecnológico de Excelencia Ciencia & Vida, Santiago, ChileCentro de Investigaciones Médicas, Laboratorio de Neurofarmacología, Escuela de Medicina, Universidad de Talca, Talca, ChileLaboratory of Neurosystems, Department of Neuroscience and Biomedical Neuroscience Institute, Faculty of Medicine, Universidad de Chile, Santiago, ChileCenter of Applied Ecology and Sustainability (CAPES), Departamento de Ecología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, ChileCenter of Applied Ecology and Sustainability (CAPES), Departamento de Ecología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, ChileDepartamento de Zoología, Facultad de Ciencias Naturales y Oceanográficas, Universidad de Concepción, Concepción, ChileCenter of Aging and Regeneration UC (CARE-UC), Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, ChileCentro de Excelencia en Biomedicina de Magallanes (CEBIMA), Universidad de Magallanes, Punta Arenas, ChileLaboratory of Neurobiology of Aging, Centro de Biología Celular y Biomedicina (CEBICEM), Facultad de Medicina y Ciencia, Universidad San Sebastián, Santiago, ChileCentro Científico y Tecnológico de Excelencia Ciencia & Vida, Santiago, Chile0GEMA Center for Genomics, Ecology and Environment, Facultad de Ciencias, Ingeniería y Tecnología, Universidad Mayor, Santiago, ChileSocial interactions have a significant impact on health in humans and animal models. Social isolation initiates a cascade of stress-related physiological disorders and stands as a significant risk factor for a wide spectrum of morbidity and mortality. Indeed, social isolation stress (SIS) is indicative of cognitive decline and risk to neurodegenerative conditions, including Alzheimer’s disease (AD). This study aimed to evaluate the impact of chronic, long-term SIS on the propensity to develop hallmarks of AD in young degus (Octodon degus), a long-lived animal model that mimics sporadic AD naturally. We examined inflammatory factors, bioenergetic status, reactive oxygen species (ROS), oxidative stress, antioxidants, abnormal proteins, tau protein, and amyloid-β (Aβ) levels in the hippocampus of female and male degus that were socially isolated from post-natal and post-weaning until adulthood. Additionally, we explored the effect of re-socialization following chronic isolation on these protein profiles. Our results showed that SIS promotes a pro-inflammatory scenario more severe in males, a response that was partially mitigated by a period of re-socialization. In addition, ATP levels, ROS, and markers of oxidative stress are severely affected in female degus, where a period of re-socialization fails to restore them as it does in males. In females, these effects might be linked to antioxidant enzymes like catalase, which experience a decline across all SIS treatments without recovery during re-socialization. Although in males, a previous enzyme in antioxidant pathway diminishes in all treatments, catalase rebounds during re-socialization. Notably, males have less mature neurons after chronic isolation, whereas phosphorylated tau and all detectable forms of Aβ increased in both sexes, persisting even post re-socialization. Collectively, these findings suggest that long-term SIS may render males more susceptible to inflammatory states, while females are predisposed to oxidative states. In both scenarios, the accumulation of tau and Aβ proteins increase the individual susceptibility to early-onset neurodegenerative conditions such as AD.https://www.frontiersin.org/articles/10.3389/fnagi.2023.1250342/fullOctodon degussocial isolation stressAmyloid-β proteintau proteininflammationoxidative stress |
| spellingShingle | Carolina A. Oliva Matías Lira Matías Lira Claudia Jara Alejandra Catenaccio Alejandra Catenaccio Trinidad A. Mariqueo Carolina B. Lindsay Francisco Bozinovic Grisel Cavieres Grisel Cavieres Nibaldo C. Inestrosa Nibaldo C. Inestrosa Cheril Tapia-Rojas Cheril Tapia-Rojas Daniela S. Rivera Long-term social isolation stress exacerbates sex-specific neurodegeneration markers in a natural model of Alzheimer’s disease Frontiers in Aging Neuroscience Octodon degus social isolation stress Amyloid-β protein tau protein inflammation oxidative stress |
| title | Long-term social isolation stress exacerbates sex-specific neurodegeneration markers in a natural model of Alzheimer’s disease |
| title_full | Long-term social isolation stress exacerbates sex-specific neurodegeneration markers in a natural model of Alzheimer’s disease |
| title_fullStr | Long-term social isolation stress exacerbates sex-specific neurodegeneration markers in a natural model of Alzheimer’s disease |
| title_full_unstemmed | Long-term social isolation stress exacerbates sex-specific neurodegeneration markers in a natural model of Alzheimer’s disease |
| title_short | Long-term social isolation stress exacerbates sex-specific neurodegeneration markers in a natural model of Alzheimer’s disease |
| title_sort | long term social isolation stress exacerbates sex specific neurodegeneration markers in a natural model of alzheimer s disease |
| topic | Octodon degus social isolation stress Amyloid-β protein tau protein inflammation oxidative stress |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1250342/full |
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