Clonal dynamics and Stereo-seq resolve origin and phenotypic plasticity of adenosquamous carcinoma

Clonal dynamics and Stereo-seq resolve origin and phenotypic plasticity of adenosquamous carcinoma

Abstract The genomic origin and development of the biphasic lung adenosquamous carcinoma (ASC) remain inconclusive. Here, we derived potential evolutionary trajectory of ASC through whole-exome sequencing, Stereo-seq, and patient-derived xenografts. We showed that EGFR and MET activating mutations w...

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Bibliographic Details
Main Authors: Ruiying Zhao, Yunhua Xu, Yedan Chen, Jiajun Zhang, Fei Teng, Sha Liao, Shengnan Chen, Qian Wu, Chan Xiang, Jiaohui Pang, Zhanxian Shang, Jikai Zhao, Hairong Bao, Hua Bao, Yang Shao, Shun Lu, Yuchen Han
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-023-00430-8

Internet

https://doi.org/10.1038/s41698-023-00430-8

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