Biased TCR gene usage in citrullinated Tenascin C specific T-cells in rheumatoid arthritis

Biased TCR gene usage in citrullinated Tenascin C specific T-cells in rheumatoid arthritis

Abstract We aimed to search for common features in the autoreactive T cell receptor (TCR) repertoire in patients with rheumatoid arthritis (RA), focusing on the newly identified candidate antigen citrullinated Tenascin C (cit-TNC). Mononuclear cells from peripheral blood or synovial fluid of eight R...

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Bibliographic Details
Main Authors: Ravi K. Sharma, Sanjay V. Boddul, Niyaz Yoosuf, Sara Turcinov, Anatoly Dubnovitsky, Genadiy Kozhukh, Fredrik Wermeling, William W. Kwok, Lars Klareskog, Vivianne Malmström
Format: Article
Language:English
Published: Nature Portfolio 2021-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-04291-8

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https://doi.org/10.1038/s41598-021-04291-8

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