Longitudinal multi-omics study reveals common etiology underlying association between plasma proteome and BMI trajectories in adolescent and young adult twins

Longitudinal multi-omics study reveals common etiology underlying association between plasma proteome and BMI trajectories in adolescent and young adult twins

Abstract Background The influence of genetics and environment on the association of the plasma proteome with body mass index (BMI) and changes in BMI remains underexplored, and the links to other omics in these associations remain to be investigated. We characterized protein–BMI trajectory associati...

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Bibliographic Details
Main Authors: Gabin Drouard, Fiona A. Hagenbeek, Alyce M. Whipp, René Pool, Jouke Jan Hottenga, Rick Jansen, Nikki Hubers, Aleksei Afonin, BIOS Consortium, BBMRI-N. L. Metabolomics Consortium, Gonneke Willemsen, Eco J. C. de Geus, Samuli Ripatti, Matti Pirinen, Katja M. Kanninen, Dorret I. Boomsma, Jenny van Dongen, Jaakko Kaprio
Format: Article
Language:English
Published: BMC 2023-12-01
Series:BMC Medicine
Subjects:
Multi-omics
Proteome
Metabolome
Transcriptome
Polygenic risk scores
Body mass index (BMI)
Online Access:https://doi.org/10.1186/s12916-023-03198-7

Internet

https://doi.org/10.1186/s12916-023-03198-7

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