Hyperactivity in Mice Induced by Opioid Agonists with Partial Intrinsic Efficacy and Biased Agonism Administered Alone and in Combination with Morphine

Hyperactivity in Mice Induced by Opioid Agonists with Partial Intrinsic Efficacy and Biased Agonism Administered Alone and in Combination with Morphine

Opioid analgesics such as morphine and fentanyl induce mu-opioid receptor (MOR)-mediated hyperactivity in mice. Herein, we show that morphine, fentanyl, SR-17018, and oliceridine have submaximal intrinsic efficacy in the mouse striatum using <sup>35</sup>S-GTPγS binding assays. While all...

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Bibliographic Details
Main Authors: Agnes Acevedo-Canabal, Travis W. Grim, Cullen L. Schmid, Nina McFague, Edward L. Stahl, Nicole M. Kennedy, Thomas D. Bannister, Laura M. Bohn
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Biomolecules
Subjects:
GPCR
biased agonism
oliceridine
partial agonist
striatum
SR-17018
Online Access:https://www.mdpi.com/2218-273X/13/6/935

Internet

https://www.mdpi.com/2218-273X/13/6/935

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