New C3H Kit N824K/WT cancer mouse model develops late-onset malignant mammary tumors with high penetrance

New C3H Kit N824K/WT cancer mouse model develops late-onset malignant mammary tumors with high penetrance

Abstract Gastro-intestinal stromal tumors and acute myeloid leukemia induced by activating stem cell factor receptor tyrosine kinase (KIT) mutations are highly malignant. Less clear is the role of KIT mutations in the context of breast cancer. Treatment success of KIT-induced cancers is still unsati...

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Bibliographic Details
Main Authors: Tanja Klein-Rodewald, Kateryna Micklich, Adrián Sanz-Moreno, Monica Tost, Julia Calzada-Wack, Thure Adler, Matthias Klaften, Sibylle Sabrautzki, Bernhard Aigner, Markus Kraiger, Valerie Gailus-Durner, Helmut Fuchs, German Mouse Clinic Consortium, Albert Gründer, Heike Pahl, Eckhard Wolf, Martin Hrabe de Angelis, Birgit Rathkolb
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-23218-5

Internet

https://doi.org/10.1038/s41598-022-23218-5

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