Vaccine-linked chemotherapy improves cardiac structure and function in a mouse model of chronic Chagas disease

Vaccine-linked chemotherapy improves cardiac structure and function in a mouse model of chronic Chagas disease

IntroductionChagas disease, caused by chronic infection with the protozoan parasite Trypanosoma cruzi, affects 6-7 million people worldwide. The major clinical manifestation of Chagas disease is chronic Chagasic cardiomyopathy (CCC), which encompasses a spectrum of symptoms including arrhythmias, hy...

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Bibliographic Details
Main Authors: Kathryn M. Jones, Elise N. Mangin, Corey L. Reynolds, Liliana E. Villanueva, Julio Vladimir Cruz, Leroy Versteeg, Brian Keegan, April Kendricks, Jeroen Pollet, Fabian Gusovsky, Maria Elena Bottazzi, Peter J. Hotez
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Trypanosoma cruzi
Chagas disease
vaccine-linked chemotherapy
cardiomyopathy
cardiac function
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2023.1106315/full

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https://www.frontiersin.org/articles/10.3389/fcimb.2023.1106315/full

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